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Astrocytes from cortex and striatum show differential responses to mitochondrial toxin and BDNF: Implications for protection of striatal neurons expressing mutant huntingtin
(BioMed Central, 2020-10)
Background: Evidence shows significant heterogeneity in astrocyte gene expression and function. We previously demonstrated that brain-derived neurotrophic factor (BDNF) exerts protective effects on whole brain primary ...
failure in ascorbic acid recycling and release from striatal astrocytes is responsible for the metabolic impairment in Huntington’s disease
(2015)
the basal ganglia and in the cerebral cortex of symptomatic HD patients. When HD animal models become behaviorally active, the
levels of ascorbic acid in striatal extracellular fluid is abnormally low in relation with the ...
Astrocytes as neural stem cells in the adult brain
(2012)
In the adult mammalian brain, bona fide neural stem cells were discovered in the subventricular zone (SVZ), the largest neurogenic niche lining the striatal wall of the lateral ventricles of the brain. In this region resides ...
Astrocytes as neural stem cells in the adult brain
(2012)
In the adult mammalian brain, bona fide neural stem cells were discovered in the subventricular zone (SVZ), the largest neurogenic niche lining the striatal wall of the lateral ventricles of the brain. In this region resides ...
Astrocytes as Neural Stem Cells in the Adult Brain
(2012)
In the adult mammalian brain, bona fide neural stem cells were discovered in the subventricular zone (SVZ), the largest neurogenic niche lining the striatal wall of the lateral ventricles of the brain. In this region resides ...
Astrocytes as Neural Stem Cells in the Adult Brain
(2012)
In the adult mammalian brain, bona fide neural stem cells were discovered in the subventricular zone (SVZ), the largest neurogenic niche lining the striatal wall of the lateral ventricles of the brain. In this region resides ...
Single early prenatal lipopolysaccharide exposure impairs striatal monoamines and maternal care in female rats
(Elsevier B.V., 2013-05-02)
Aims: Environmental information received by a mother can induce a phenotype change in her offspring, commonly known as a maternal effect (trans-generational effect). The present work verified the effects of lipopolysaccharide ...
Melanocortin 4 receptor activation protects striatal neurons and glial cells from 3-nitropropionic acid toxicity
(Academic Press Inc Elsevier Science, 2019-01)
α-Melanocyte stimulating hormone (α-MSH) is a melanocortin which exerts potent anti-inflammatory and anti-apoptotic effects. Melanocortin 4 receptors (MC4R) are abundantly expressed in the brain and we previously demonstrated ...